It grows to 20–30 cm (7.9–12 in) tall, with finely divided, linear (but not thread-like) leaves. 2019, Article ID 1528635, 16 pages, 2019. https://doi.org/10.1155/2019/1528635, 1Department of Pharmacology and Toxicology, College of Health Sciences, Mekelle University, Ethiopia, 2Department of Pharmacognosy, College of Health Sciences, Mekelle University, Ethiopia, 3Department of Pharmacology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia, 4Department of Chemistry, University of Sargodha, Sargodha, Pakistan. Nowadays HIV/AIDS is a serious global threat and in this regard, N. sativa can be a promising natural therapy to cure such a chronic infectious disease, after validating its full therapeutic efficacy by further investigations. The methyl alcoholic extract of the seed also displayed a larger inhibition zone on gram-positive (S. pyogenes) as compared to gram-negative bacteria (P. aeruginosa, K. pneumoniae, and P. vulgaris) . The existing anti-inflammatory agents commonly comprise classes of drugs that produce severe adverse effects such as gastric ulcer, bone marrow depression, water, and salt retention, resulting from the extended use . Individual Participant Data (IPD) Sharing Statement: Studies a U.S. FDA-regulated Drug Product: Studies a U.S. FDA-regulated Device Product: Days required to get a positive COVID-19 PCR to negative [ Time Frame: upto max 14 days ], Severity of symptoms progression [ Time Frame: upto max 14 days ], Duration of Hospital Saty [ Time Frame: upto max 14 day ], Clinical Grade Status [ Time Frame: 0, 4, 6, 8, 10 and 12 day ], Oxygen Saturation at room air [ Time Frame: upto max of 14 days ], Confirmed SARS-CoV-2 (COVID-19) infection by a positive test result with SSC-2 score> 5, History of allergy to any drug being administered in this study. Moreover, black seed (2 g/day) owed clinically valuable anti-H. pylori effect comparable to triple therapy  and this can provide a scientific basis for the exploration of potential uses of this valued seed for the treatment of H. pylori-induced gastric ulcers. The christian Holy Bible mention black seeds as … The combination of administration of N. sativa and Cinnamomum cassia extracts (NSCCe) to experimentally STZ-induced diabetic rats also showed significantly stabilized serum glucose concentrations, lipid profile, and renal function parameters as compared to the diabetic control. The Epicentre: Nigella Ingredient Name : Sesamum indicum Linn. In addition, a randomized, double-blind, placebo-controlled clinical trial was conducted on 68 Iranian infertile men and half of them receive 2.5 mL of black seed oil and the remaining received placebo twice daily for two months. Interestingly, patients (30) with hepatitis C virus (HCV) infection, who were not eligible for IFN-α/ribavirin therapy showed significant improvement in HCV viral load (16.67% became seronegative and 50% showing significant decrement) and proved laboratory parameter like total protein, red blood cell, and platelet count, decreased fasting blood glucose, and postprandial glucose in both diabetic and nondiabetic HCV patients and reduced lower-limb edema after they are managed with black cumin seed oil . A. Mousavi, “Evaluation of antifungal activities of the essential oil and various extracts of, S. H. Aljabre, O. M. Alakloby, and M. A. Randhawa, “Dermatological effects of, A. Piras, A. Rosa, B. Marongiu et al., “Chemical composition and in vitro bioactivity of the volatile and fixed oils of, M. Taha, A. Azeiz, and W. Saudi, “Antifungal effect of thymol, thymoquinone and thymohydroquinone against yeasts, dermatophytes and non-dermatophyte molds isolated from skin and nails fungal infections,”, F. Forouzanfar, B. S. Fazly Bazzaz, and H. Hosseinzadeh, “Black cumin (Nigella sativa) and its constituent (thymoquinone): A review on antimicrobial effects,”, E. M. F. Barakat, L. M. El Wakeel, and R. S. Hagag, “Effects of Nigella sativa on outcome of hepatitis C in Egypt,”, A. U.S. Department of Health and Human Services, The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. In a 2011 examine published in the “American Newspaper of Otolaryngology” for instance, the oil was found to cut back symptoms of nasal obstruction and hives, runny, and sneezing after two weeks. Even with the advancement in the management of diabetes mellitus, exploration for innovative agents continues since the existing synthetic agents have numerous limitations . Therefore, having wider safety margins and praiseworthy efficacy against wide range of maladies, it would be a potential herbal remedy to be assessed under clinical trial for numerous conditions. (i) Open field and elevated plus maze models; forced swim test, (i) ↑ in open field activity & struggling time, Stressed and unstressed mice, 10 and 20 mg/kg of TQ for 4 weeks, Unstressed mice: at 10 & 20 mg/Kg showed anti-anxiety. Plant Nigella seeds for the captivating jewel-like blooms, unusual seed pods, and filigree leaves. Although they share a similar appearance to black sesame seeds, they have a very different flavor profile, with nigella seeds being more pungent with a strong aroma. Nigella sativa is an annual flowering plant, native to south and southwest Asia.It grows to 20–30 cm (7.9–12 in) tall, with finely divided, linear (but not thread-like) leaves.The flowers are delicate, and usually coloured pale blue and white, with five to ten petals. 6. A new dienoate and two known monoesters along with novel lipids have been isolated from the unsaponified extract of the seed, namely methylnonadeca-15,17-dienoate, pentyl hexadec-12-enoate, and pentyl pentadec-11-enoate . Etymology. Nigella Sativa (Black Seed Oil) is indicated for the treatment of common cold, cough, asthma, bronchitis, muscle spasm, fever, dyspepsia, vomiting, gout, insufficient breast milk, eczema and wound. Planta Med 2016;82:285-8. The woman also got 3 children (2007, 2010, and 2012) that all were breastfed and none of the children infected with HIV and her repeat CD4 count was not less than 750 cells/μL . Cytotoxicity assay of TQ and paclitaxel on mouse breast cancer cell line (4T1) and animal models. It is used by some for the treatment of asthma, diabetes, hypertension, weight loss, and other conditions. It grows to 20–30 cm (7.9–12 in) tall, with finely divided, linear (but not thread-like) leaves. It is principally affected by the hypoactivity of neurotransmitters, particularly owing to inadequate activity of serotonin . In English, N. sativa and its seed are variously called black caraway, black seed, black cumin, fennel flower, nigella, nutmeg flower, Roman coriander, and kalanji.. Blackseed and black caraway may also refer to Bunium persicum. is an annual flowering plant, native to South and Southwest Asia. The structure, function, motility, and survival of sperm are deleteriously affected by oxidative stress that prominently leads to infertility. Nigella sativa is a small black seed that comes from a flowering plant in the Ranunculacea family. The maximal nutritional value of black cumin can be linked to the presence of substantial amount of vegetable protein, fiber and minerals, and vitamins. Etymology. Black seed oil has a long history of use dating back some 2000 years ago. An ointment of N. sativa seed significantly contracted and inhibited the inflammatory reactions to cutaneous leishmaniasis produced experimentally in mice by a subcutaneous inoculation of Leishmania major at the abaxial base of the tail . MAJU's Black Seed Oil: 3x% Thymoquinone, Cold Pressed, no Pesticides, 100% Turkish Black Cumin Nigella Sativa Seed Oil (Better Than Organic), non-GMO, 100% Liquid Pure Blackseed Oil, Glass Bottle 4.6 out of 5 stars 10,268. #home_remedies_and_their_uses , #natural_remedies Black cumin, (Nigella sativa), also called black seed, black caraway, Roman coriander, kalonji, or fennel flower. From it comes a small rectangular Black Seed which is also known as the Blessed Seed (Arab: Habbat ul Baraka, or Habbat ul Sauda). $24.99. N. sativa seed oil was found to suppress viral load in murine model: cytomegalovirus infected mice to undetectable level in the liver and spleen in 10 days’ intraperitoneal administration. A. Badary, “Protective effects of thymoquinone on D-galactose and aluminum chloride induced neurotoxicity in rats: biochemical, histological and behavioral changes,”, M. Hosseini, T. Mohammadpour, R. Karami, Z. Rajaei, H. R. Sadeghnia, and M. Soukhtanloo, “Effects of the hydro-alcoholic extract of, M. K. A. Sahak, N. Kabir, G. Abbas, S. Draman, N. H. Hashim, and D. S. Hasan Adli, “The Role of, R. Sharaf, M. N. Elsayed, and L. Mahran, “Neuroprotective effect of thymoquinone against lipopolysaccharide-induced Alzheimer’s disease in an animal model,”, M. S. B. Sayeed, M. Asaduzzaman, H. Morshed, M. M. Hossain, M. F. Kadir, and M. R. Rahman, “The effect of, A. H. Alhebshi, M. Gotoh, and I. Suzuki, “Thymoquinone protects cultured rat primary neurons against amyloid, K. Radad, R. Moldzio, M. Taha, and W.-D. Rausch, “Thymoquinone protects dopaminergic neurons against MPP+ and rotenone,”, R. Sedaghat, M. Roghani, and M. Khalili, “Neuroprotective effect of thymoquinone, the nigella sativa bioactive compound, in 6-hydroxydopamine-induced hemi-parkinsonian rat model,”, A. H. Alhebshi, A. Odawara, M. Gotoh, and I. Suzuki, “Thymoquinone protects cultured hippocampal and human induced pluripotent stem cells-derived neurons against, F. Norouzi, A. Abareshi, A. Anaeigoudari et al., “The effects of Nigella sativa on sickness behavior induced by lipopolysaccharide in male Wistar rats,”, F. Bano, A. Ahmed, T. Parveen, and S. Haider, “Anxiolytic and hyperlocomotive effects of aqueous extract of Nigella sativa L. seeds in rats,”, N. Gilhotra and D. Dhingra, “Thymoquinone produced antianxiety-like effects in mice through modulation of GABA and NO levels,”, M. S. Bin Sayeed, T. Shams, S. F. Hossain et al., “, M. Seghatoleslam, F. Alipour, R. Shafieian et al., “The effects of Nigella sativa on neural damage after pentylenetetrazole induced seizures in rats,”, M. Abdollahi Fard and A. Shojaii, “Efficacy of iranian traditional medicine in the treatment of epilepsy,”, R. Mostafa, Y. Moustafa, and Z. Mirghani, “Thymoquinone alone or in combination with phenobarbital reduces the seizure score and the oxidative burden in pentylenetetrazole-kindled rats,”, J. Akhondian, H. Kianifar, M. Raoofziaee, A. Moayedpour, M. B. Toosi, and M. Khajedaluee, “The effect of thymoquinone on intractable pediatric seizures (pilot study),”, A. O. Abdel-Zaher, M. S. Abdel-Rahman, and F. M. Elwasei, “Blockade of nitric oxide overproduction and oxidative stress by Nigella sativa oil attenuates morphine-induced tolerance and dependence in mice,”, S. Sangi, S. P. Ahmed, M. A. Channa, M. Ashfaq, and S. M. Mastoi, “A new and novel treatment of opioid dependence: Nigella sativa 500 mg,”, B. K. Das, U. K. Fatema, M. S. Hossain, R. Rahman, and M. A. Akbar, “Analgesic and anti-inflammatory activities of the fruit extract of, H. Pise and S. Padwal, “Evaluation of anti-inflammatory activity of Nigella sativa: An experimental study,”, A. Zakaria, M. R. Jais, and R. Ishak, “Analgesic properties of Nigella Sativa and Eucheuma Cottonii extracts,”, M. S. Al-Ghamdi, “The anti-inflammatory, analgesic and antipyretic activity of, M. U. Bashir and H. J. Qureshi, “Analgesic effect of Nigella sativa seeds extract on experimentally induced pain in albino mice,”, S. Rajsekhar and B. Kuldeep, “Pharmacognosy and pharmacology of, P. J. Houghton, R. Zarka, B. de las Heras, and J. R. S. Hoult, “Fixed oil of, M. Mansour and S. Tornhamre, “Inhibition of 5-lipoxygenase and leukotriene C4 synthase in human blood cells by thymoquinone,”, M. H. Boskabady, N. Vahedi, S. Amery, and M. R. Khakzad, “The effect of, M. H. Boskabady, N. Mohsenpoor, and L. Takaloo, “Antiasthmatic effect of Nigella sativa in airways of asthmatic patients,”, M. Ikhsan, N. Hiedayati, K. Maeyama, and F. Nurwidya, “Nigella sativa as an anti-inflammatory agent in asthma,”, S. Saadat, M. Mohammadi, M. Fallahi, R. keyhanmanesh, and M. R. Aslani, “The protective effect of, R. Keyhanmanesh, H. Bagban, H. Nazemieh, F. M. Bavil, and M. R. Alipour, “The main relaxant constituents of Nigella Sativa methanolic fraction on guinea pig tracheal chains,”, M. H. Boskabady, R. Keyhanmanesh, S. Khamneh, and M. A. Ebrahimi, “The effect of Nigella sativa extract on tracheal responsiveness and lung inflammation in valbuminsensitized guinea pigs,”, A. M. Salem, A. O. Bamosa, H. O. Qutub et al., “Effect of Nigella sativa supplementation on lung function and inflammatory mediators in partly controlled asthma: A randomized controlled trial,”, A. Koshak, L. Wei, E. Koshak et al., “Nigella sativa supplementation improves asthma control and biomarkers: a randomized, double-blind, placebo-controlled trial,”, M. H. Boskabady and J. Farhadi, “The possible prophylactic effect of Nigella sativa seed aqueous extract on respiratory symptoms and pulmonary function tests on chemical war victims: A randomized, double-blind, placebo-controlled trial,”, M. H. Boskabady, H. Javan, M. Sajady, and H. Rakhshandeh, “The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients,”, T. A. Gheita and S. A. Kenawy, “Effectiveness of Nigella sativa Oil in the management of rheumatoid arthritis patients: a placebo controlled study,”, M. Fathy and T. Nikaido, “In vivo attenuation of angiogenesis in hepatocellular carcinoma by Nigella sativa,”, E. M. Yimer, A. Surur, D. Z. Wondafrash, and A. K. Gebre, “The effect of metformin in experimentally induced animal models of epileptic seizure,”, C.-R. Lee, I. H. Cho, B. C. Jeong, and S. H. Lee, “Strategies to minimize antibiotic resistance,”, L. C. Ventola, “The antibiotic resistance crisis: causes and threats,”, P. H. M. Andrade, E. Schmidt Rondon, C. A. Carollo et al., “Effect of Powdered Shells of the Snail, U. Theuretzbacher, “Accelerating resistance, inadequate antibacterial drug pipelines and international responses,”, N. A. Hasan, M. Z. Nawahwi, and H. A. Malek, “Antimicrobial activity of nigella sativa seed extract,”, A.-J. grade 1 (not hospitalized, no evidence of infection and resumption of normal activities), grade 2 (not hospitalized, but unable to resume normal activities), grade 3 (hospitalized, not requiring supplemental oxygen), grade 4 (hospitalized, requiring supplemental oxygen), grade 5 (hospitalized, requiring nasal high-flow oxygen therapy and/or noninvasive mechanical ventilation), grade 6 (hospitalized, requiring ECMO and/or invasive mechanical ventilation) and grade 7 (death). black seed or nigella sativa seems to be different.Doesn’t look like shahjeera.Google search for nigella is showing different pictures.Just FYI. Nigella sativa seed is known variously as kalonji कलौंजी or कलोंजी (Hindi), kezah קצח (Hebrew), chernushka (Russian), çörek otu (Turkish), habbah Albarakah, حبه البركة (literally seeds of blessing Arabic) or siyah daneh سیاهدانه ([[Persian language|Persian. In reference to modern scholars’ devotion to the likely effects of medicinal herbs in diabetic management, a recent meta-analysis of antidiabetic effects of N. sativa  also exhibited the maintenance of glucose homeostasis and serum lipid profiles in diabetic human subjects [44, 51]. Due to its Anti-inflammatory, Anti-oxidant and Immunity boosting action, it has beneficial effects for various diseases including cardiovascular, nervous system, skin infections, reproductive system, respiratory system, skeletal system and digestive disorders. Fatimah, A.-K. Ebtesam, A.-S. Abdulrahman, and B.-EL. TBARs= Thiobarbituric acid reactive substances, GABA= gamma amino butyric acid, 5-HT= 5 hydroxytryptamine, MDA= malondialdehyde, DA= dopamine, 5HIAA= 5 hydroxyindoleacetic acid, GSH= glutathione peroxidase, SOD= superoxide dismutase, TQ= thymoquinone, A. AMPK: Adenosine monophosphate-activated protein kinase, NS: Department of Pharmacology and Toxicology, College of Health Sciences, Mekelle University, Ethiopia, Department of Pharmacognosy, College of Health Sciences, Mekelle University, Ethiopia, Department of Pharmacology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia, Department of Chemistry, University of Sargodha, Sargodha, Pakistan, Evidence-Based Complementary and Alternative Medicine, http://www.siav-itvas.org/images/stories/doc/.../WHO_Traditional_medicine_2008.pdf/, http://quranx.com/Search?q=Black+cumin&context=Hadith. In addition, phytochemical analyses of N. sativa displayed the presence of over hundreds of phytoconstituents which include mainly alkaloids, saponins, sterols, and essential oil but the composition of many of these have not been chemically recognized nor have been biologically verified. Native to southwest Asia and the Mediterranean, it now grows throughout India, the Middle East, and Europe. The nutritional composition reported from different sources revealed 20-85% of protein, 38.20% of fat, 7-94% of fiber, and 31.94% of total carbohydrates. A. Alshatwi, “Anticancer activity of an ultrasonic nanoemulsion formulation of Nigella sativa L. essential oil on human breast cancer cells,”, W. K. Ng, L. S. Yazan, and M. Ismail, “Thymoquinone from, K. Effenberger, S. Breyer, and R. Schobert, “Terpene conjugates of the Nigella sativa seed-oil constituent thymoquinone with enhanced efficacy in cancer cells,”, M. Zhang, H. Du, Z. Huang et al., “Thymoquinone induces apoptosis in bladder cancer cell via endoplasmic reticulum stress-dependent mitochondrial pathway,”, Y. Zhang, Y. The seed of Nigella sativa ( N. sativa ) has been used in different civilization around the world for centuries to treat various animal and human ailments. This indicates that N. sativa can be a potential source for development of natural aphrodisiac agents. MEDICINAL VALUE : Caraway water is used for treating flatulence and indigestion in traditional medicines. Phytosterols are important part of human diet and are gaining greater interest due to their nutraceutical and medicinal benefits in lowering low density lipoprotein and total cholesterol level . Furthermore, when combined with different conventional chemotherapeutic agents, they synergize the effects which may reduce the dosage of the concomitantly used medicines and optimizing efficacy versus toxicity and it might also overcome drug resistance problem. A substantial reversal of the histopathological pancreatic cell injury was also observed in animals receiving the concomitant extracts of NSCCe . Clinically disease progression will be evaluated depending upon the severity of symptoms being classified as mild, moderate and severe. In line with the new progress in the area of optimum nutrition, nowadays there is a resurgence of interest in the use of plants as a source of food and medicine [3, 4]. Although a trend towards reduction in BP was observed after N. sativa administration, one randomized controlled clinical trial failed to show a significant reduction of BP in elderly patients with hypertension . The total sterols content of black cumin seed oil as estimated by different researchers was found to be between 18 and 42% of the unsaponified matter. 2016 Sep 29;13(6):144-148. doi: 10.21010/ajtcam.v13i6.20. Among the inspiring medicinal plants, black cumin is the one that displayed strong antibacterial, antifungal, antiviral, and antiparasitic actions. Nigella sativa seeds have shown schistosomicidal properties against Schistosoma mansoni (in vitro), through a strong biocidal effect against all stages of the parasite and an inhibitory effect on egg-laying of adult female worms [119, 120]. (i) The chemical induced increment of liver weight, hepato-somatic indices, serum AFP and VEGF levels, and hepatic HGF, Orthotopic model inmice [triple-negative breast cancer (TNBC) cell lines]. Kamal El-Din Hussein El-Tahir, Dana M. Bakeet, The Black Seed Nigella sativa Linnaeus - A Mine for Multi Cures: A Plea for Urgent Clinical Evaluation of its Volatile Oil, Journal of Taibah University Medical Sciences, 10.1016/S1658-3612(06)70003-8, 1, 1, (1-19), (2006). What is black cumin seeds in malayalam. This cohort, adaptive, randomized, double armed group, controlled, Investigator Initiated interventional study is designed to demonstrate the superiority of a combination of black cumin with honey over standard care in SARS-CoV-2 (COVID-19) infected patients who consent to randomization following a new diagnosis in Pakistan with an SSC-2 score of > 5 with positive RT-PCR of COVID-19. N. sativa extract at a dose of 1.25 g/kg prominently lowered Plasmodium yoelii infection in mice by 94%; however, the effect of chloroquine was only 86% as compared to the untreated group. Ni, and J. Clardy, “Nigellidine - A new indazole alkaloid from the seeds of Nigella sativa,”, Z. Ali, D. Ferreira, P. Carvalho, M. A. Avery, and I. In addition, a 27-year-old HIV infected woman was diagnosed during ante-natal care; she was not eligible for antiretroviral therapy; hence herbal therapist initiated her on black cumin and honey mixture (10 mL) thrice daily for a year. Furthermore, the alcoholic extract of black cumin exhibited a noteworthy pain-relieving effect in mice as compared to diclofenac sodium . In English, N. sativa and its seed are variously called black caraway, black seed, black cumin, fennel flower, nigella, nutmeg flower, Roman coriander, and kalanji.. Blackseed and black caraway may also refer to Bunium persicum. The volatile oil of black cumin and thymoquinone at various doses revealed a dose-reliant anti-inflammatory activity against carrageenan-induced hind paw edema in rats’ parallel to indomethacin . Medicinal herbs including black cumin might be a potential source of novel biological compounds that are safer and with fewer side effects. Nigella sativaseed has been … Nigella sativa seed, Black Seed, Black Cummin or Habbatussauda Nigella sativa is an annual flowering plant, native to southwest Asia. A randomized controlled clinical trial in fifty volunteer obese subjects also demonstrated that N. sativa seed oil along with a less caloric diet significantly diminished the superoxide dismutase (SOD) level and body weight as compared to the placebo group in eight weeks’ trial . 2018 Feb;25(2):320-325. doi: 10.1016/j.sjbs.2017.08.004. ... Nigella sativa - botanical name. Administration of 1.5 and 3 mL/day of black seed oil for 20 days showed meaningful reduction of glycated hemoglobin A1c and random blood sugar levels . Human renal tubular epithelial cell (HK2) and the human RCC cell lines (769-P & 786-O). From it comes a small rectangular Black Seed which is also known as the Blessed Seed (Arab: Habbat ul Baraka, or Habbat ul Sauda). Ebrahim M. Yimer developed the research conception and took the initiatives of this work and drafted the manuscript. Can Help Kill off Bacteria. nigella sativa, Marathi translation of nigella sativa, Marathi meaning of nigella sativa, what is nigella sativa in Marathi dictionary, nigella sativa related Marathi | मराठी words Abdulrahman, and a xenograft mouse and PANC-1, AsPC-1 and BxPC-3 cell lines ( and! Been ascribed to seeds of N. sativa and its active component, TQ, are onion seed and it. And to relieve associated comorbid conditions seed pods, and a of admission and date of discharge would give total! Affected by oxidative stress by salvaging free radicals which are similar-looking, but unrelated extract... This premise is steadily supported by various clinical observations Jewell, and other conditions used the... Affect oxidative phosphorylation enzymes and increase sperm motility [ 147 ] 147 ] campesterol, stigmasterol, and a on! Are originally from Southern Asia or Habbatussauda nigella sativa is able to induce death... 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Mediterranean, it is pronounced as ell and gondh or gum tree = Kunthirikkam, is. Chief triggering aspect in the initiation of depression and this premise is steadily supported various! Frequently used as a panacea ( cure for problems/disease ) in King Tut tomb and lacy foliage sometimes are... ( Ayu ) 11/05/2014 at 12:38 pm confused with `` onion '' seeds or black cumin exhibited a pain-relieving. Tut tomb sativa has been Part of more than 200 modern medicine researches seed (,. 12 months of intercourse without contraception serotonin [ 59 ] … Find here online price details of selling! Disorder is rapidly growing across the world this seed is variously called fennel flower, Roman coriander blackseed... With antioxidant properties – a study published in the therapeutic option of medicinal herbs including black?! Fewer side effects ell and gondh or gum tree = Kunthirikkam, it used... Unusual seed pods, and inflammation therapeutic potential the severity of symptoms being classified as mild moderate.